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Australian Centre for Blood Diseases

Applications have closed.

Project code

Project Title

Commencement date  

Value

Pre-requisite Units

Project Contact

1068

To determine the role of tissue type plasminogen activator (t-PA) in the progression and severity of multiple sclerosis

21/11/10 (start dates flexible)

$250 x 6-10 weeks ($1,500-$2,500 total)

None

A/Prof Robert L Medcalf 

Robert.Medcalf@monash.edu 

1069 To identify the domain in the tissue-type plasminogen activator molecule required to modulate blood brain barrier permeability using an in vitro model 21/11/10 (start dates flexible)

$250 x 6-10 weeks ($1,500-$2,500 total)

None

A/Prof Robert L Medcalf 

Robert.Medcalf@monash.edu

1070

Manipulation of the plasmin-antiplasmin system to dissolve blood clots 21/11/10 (start dates flexible)

$250 x 6-10 weeks ($1,500-$2,500 total)

None

A/Prof Paul Coughlin & Dr Anita Horvath

Paul.Coughlin@monash.edu

Anita.Horvath@monash.edu

1071 Investigate the interaction of plasmin kringle domains with the antiplasmin 21/11/10 (start dates flexible)

$250 x 6-10 weeks ($1,500-$2,500 total)

None

A/Prof Paul Coughlin & Dr Anita Horvath

Paul.Coughlin@monash.edu

Anita.Horvath@monash.edu

1072 Physiological and pathological significance of receptor shedding from platelets, and assessment of plasma soluble GPVI as a biomarker of thrombotic abnormalities 21/11/10 (start dates flexible)

$250 x 6-10 weeks ($1,500-$2,500 total)

None

Dr Elizabeth Gardiner

Elizabeth.Gardiner@monash.edu

1073 In cold blood - the trouble with transfusion platelets 21/11/10 (start dates flexible)

$250 x 6-10 weeks ($1,500-$2,500 total)

None

Dr Jane Arthur

Jane.Arthur@monash.edu

1074 Identification of binding sites for GPIb-IX-V ligands, and how these interactions regulate cell adhesion and coagulation 21/11/10 (start dates flexible)

$250 x 6-10 weeks ($1,500-$2,500 total)

None

Dr Robert Andrews

Robert.Andrews@monash.edu

1075 Investigating new approaches to dissolve blood clots  21/11/10 (start dates flexible)

$250 x 6-10 weeks ($1,500-$2,500 total)

None

Dr Simone M Schoenwaelder & Prof Shaun P Jackson

Simone.Schoenwaelder@monash.edu

1076 Investigating a new anti-clotting approach: Regulation of platelet adhesion and thrombus formation by the GPIb/V/IX adhesion receptor  21/11/10 (start dates flexible)

$250 x 6-10 weeks ($1,500-$2,500 total)

None

Dr Sue Cranmer

Sue.Cranmer@monash.edu

1077 Investigation of the functional interplay between platelets and neutrophils 21/11/10 (start dates flexible)

$250 x 6-10 weeks ($1,500-$2,500 total)

None

Dr Yuping

Yuanyuping.yuan@monash.edu

1078 Defining the function of thrombin receptors on human platelets during thrombosis 21/11/10 (start dates flexible)

$250 x 6-10 weeks ($1,500-$2,500 total)

None

Dr Justin Hamilton

Justin.Hamilton@monash.edu

1079 Investigation of the effects of new anti-cancer agents on platelet function: A role for apoptosis in regulating platelet reactivity 21/11/10 (start dates flexible)

$250 x 6-10 weeks ($1,500-$2,500 total)

None

Prof Shaun Jackson & Dr Simone Schoenwaelder

Shaun.Jackson@monash.edu

Simone.Schoenwaelder@monash.edu

1080 A New Class of Antithrombotic Agents Investigating the role of PI 3-kinases in haemostasis and thrombosis 21/11/10 (start dates flexible)

$250 x 6-10 weeks ($1,500-$2,500 total)

None

Prof Shaun Jackson

Shaun.Jackson@monash.edu

1081 Investigating platelet hyperactivity in Diabetes  21/11/10 (start dates flexible)

$250 x 6-10 weeks ($1,500-$2,500 total)

None

Prof Shaun Jackson

Shaun.Jackson@monash.edu

1082 Targeting P13-Kinases in leukaemic cells: Looking for partners in crime 21/11/10 (start dates flexible)

$250 x 6-10 weeks ($1,500-$2,500 total)

None

Dr Julie McManus & Dr Andrew Wei

Ju.McManus@alfred.org.au

1083 The effect of novel anti-cancer drugs on the ability of bone marrow stroma to support acute myeloid leukaemia survival and proliferation 21/11/10 (start dates flexible)

$250 x 6-10 weeks ($1,500-$2,500 total)

None

Dr Andrew Wei

andrew.wei@alfred.org.au

1084 Androgens: more strings to the bow. Understanding androgen mediated erythropoiesis. 21/11/10 (start dates flexible)

$250 x 6-10 weeks ($1,500-$2,500 total)

None

Dr Julie McManus & Dr Andrew Wei

Ju.McManus@alfred.org.au

1085 What turns you on? Determining activation signals for platelets during thrombosis 21/11/10 (start dates flexible)

$250 x 6-10 weeks ($1,500-$2,500 total)

None

Dr Justin Hamilton

Justin.Hamilton@monash.edu

1086 Sirtuins: Novel therapeutic targets for Multiple Myeloma 21/11/10 (start dates flexible)

$250 x 6-10 weeks ($1,500-$2,500 total)

None

Dr Tiffany Khong

T.Khong@alfred.org.au

1087 Targeting heat shock response as a potential therapeutic target in multiple myeloma 21/11/10 (start dates flexible)

$250 x 6-10 weeks ($1,500-$2,500 total)

None

Dr Tiffany Khong

T.Khong@alfred.org.au

1088 Haematopoietic and Leukemia Stem Cell Self-Renewal via Asymmetric Cell Division 21/11/10 (start dates flexible)

$250 x 6-10 weeks ($1,500-$2,500 total)

None

Dr Stephen Ting

Stephen.Ting@monash.edu

1089 Anti-leukemic Effects and Molecular Mechanisms of Action of Novel Histone Deacetylase Inhibitors and Demethylating Agents in In vitro and In vivo Models of Myelodysplastic Syndrome 21/11/10 (start dates flexible)

$250 x 6-10 weeks ($1,500-$2,500 total)

None

Dr Anthony Dear

anthony.dear@monash.edu

1090 Histone Deacetylase Inhibitors as Novel Treatments for Vascular Disease 21/11/10 (start dates flexible)

$250 x 6-10 weeks ($1,500-$2,500 total)

None

Dr Anthony Dear

anthony.dear@monash.edu

1091 Understanding how CD4 regulatory T cell development in the thymus is controlled 21/11/10 (start dates flexible)

$250 x 6-10 weeks ($1,500-$2,500 total)

None

Prof Steve Gerondakis & Dr George Grigoriadis

Steven.gerondakis@monash.edu

1092 Exactly what role does the NF-kappaB pathway play in multiple myeloma? 21/11/10 (start dates flexible)

$250 x 6-10 weeks ($1,500-$2,500 total)

None

Prof Steve Gerondakis & Dr George Grigoriadis

Steven.gerondakis@monash.edu